A model-free approach for detecting interactions in genetic association studies
نویسندگان
چکیده
منابع مشابه
A Bayesian hierarchical model for detecting haplotype-haplotype and haplotype-environment interactions in genetic association studies.
OBJECTIVE Genetic association studies based on haplotypes are powerful in the discovery and characterization of the genetic basis of complex human diseases. However, statistical methods for detecting haplotype-haplotype and haplotype-environment interactions have not yet been fully developed owing to the difficulties encountered: large numbers of potential haplotypes and unknown haplotype pairs...
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A genetic model-free method for the meta-analysis of genetic association studies is described that estimates the mode of inheritance from the data rather than assuming that it is known. For a bi-allelic polymorphism, with G as risk allele and g as wild-type, the genetic model depends on the ratio of the two log odds ratios, lambda = log OR(Gg)/log OR(GG), where OR(GG) compares GG with gg and OR...
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ژورنال
عنوان ژورنال: Briefings in Bioinformatics
سال: 2013
ISSN: 1467-5463,1477-4054
DOI: 10.1093/bib/bbt082